Pemetrexed disodium hydrate CAS NO.357166-30-4

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Character Almost-white or light yellow unfixed powder, smell-less, hygroscopic freely. Solubility Soluble in water very freely, in ethanol or chloroform or ethyl ether hardly. Specific optical rotation +10°－+16° Identification (1)The product appears flame reaction of sodium salt. (2)UV:Max absorption at 225nm wavelength. (3)IR:Meet the requirements. PH 6.5－8.0 Clarity and color of solution Meet the requirements. Related substance Max single impurity≤0.1% Total impurity≤0.5% Optical isomer ≤0.500% Heavy Metal <20ppm ethanol Dichloromethane ethyl acetate DMF ≤0.500% ≤0.060% ≤0.500% ≤0.088% Water 7.2%－10.2% Assay Not less than 98.50%, calculated on the anhydrous basis.